Your TriMix FAQs Answered

You have questions. We have answers. Whether it’s “How do I get a TriMix prescription online?” or “What is TriMix used for?”, let us help address your most frequently asked questions here.

What is TriMix used for?

TriMix injections are used to treat erectile dysfunction. This injectable medication consists of three active ingredients — alprostadil, papaverine and phentolamine. These ingredients combined help to relax, expand and fill the corpus cavernosum (erectile tissue) with blood, which results in an erection very quickly after it’s been administered. Learn all about TriMix injections now.

How long do the results of TriMix injections last?

Erections achieved from a TriMix injection should last between one and two hours. Many users do not experience erections longer than this. However, if you experience an erection lasting longer than two hours, you’ll want to apply the antidote to the medication, which is called Phenylephrine. You’ll apply the Phenylephrine the same way you apply the TriMix medication. First, draw up air into the syringe, and then insert the syringe into the vial of Phenylephrine. Slowly draw back 50 units of Phenylephrine into the syringe. Pull the syringe straight out of the vial and then re-cap the front of the syringe. You’ll want to inject one inch above the base of the penis at the 10 o’clock or 2 o’clock position. You want to make sure that you avoid any veins. And again, you’ll want to massage the area of entry for about one minute right after you administer the medication. You may also apply an ice pack. If your erection still persists after another hour, seek immediate medical attention.

Are TriMix injections effective?

Yes! TriMix is 90% effective. According to the American Urologic Association, intracavernous ED injections are the most effective non-surgical treatment.

Is TriMix safe to use?

Absolutely. Since 1983, intracavernous injections like TriMix have proven to be the most effective non-surgical treatment for erectile dysfunction (ED), according to the American Urologic Association.

How do TriMix injections compare to oral ED medications?

TriMix is an injectable alternative to consumable pills (PDE5 inhibitor tablets like Viagra®, Levitra® or Cialis®) that is designed to treat symptoms of erectile dysfunction. It has a 90% success rate, compared to only a 60% success rate for men using oral ED medications. It consists of three drugs: phentolamine, papaverine and alprostadil, and can be especially effective for patients who are unable to take a consumable alternative because they’ve experienced negative side effects or they’re currently taking nitrates or beta-blockers for heart issues.

TriMix can trigger an automatic erection in less than 5 minutes, unlike oral medications which can take an average of 60 minutes to start working.

How does TriMix work?

When injected into the penis, TriMix’s blend of three vasodilators causes the corpus cavernosum to relax, expand and fill with blood. This can cause a powerful erection in 5 minutes or less.

How do you inject TriMix?

– First, ensure that you have washed your hands and penis to ensure proper hygiene before the injection.

– Once you’ve properly assembled the medication, find the proper location on the shaft of the penis to inject, which is located between the base and the mid-portion of the penis. Avoid any visible veins as well as the midline of the penis. You want to aim slightly to the left or right of the midline in order to prevent potential damage to the urethra or penile arteries.

– Grasp and pull the head of the penis toward the side of your leg with the index finger and thumb (use the left hand, if right-handed). While maintaining light tension, select a site for injection.

– With a steady and continuous motion, penetrate the skin with the needle at a 90-degree angle. The needle should then be advanced to the hub. Slight resistance is encountered as the needle passes into the proper position within the erectile tissue (corporeal body).

– Inject the TriMix medication into the corpus cavernosum for approximately 4 seconds. Once the needle is in, you should pull it back a little until a small amount of blood flows back into the syringe. When injecting, you should feel the same amount of pressure as you would by simply injecting it into the air (minimal resistance). If there’s greater pressure than that, it’s being applied to the wrong spot.

– Withdraw the needle from the penis and apply compression to the injection site for approximately 1 minute. Several minutes of compression may be required to avoid bleeding, especially if you use aspirin.

– Replace the cap on the needle and dispose of it properly.

– For more detailed information about preparing and administering TriMix, please visit our TriMix self-injections instructions page.

What is the correct TriMix dosage I should take?

The initial dose should be 0.05 cc to 0.2 ccs, depending on the patient’s level of ED. Wait 48 hours before increasing the dosage. Increase by 0.025 ccs to 0.050 ccs until a satisfactory dose is reached. The maximum dose is 0.50 cc.
Do not be discouraged by a poor result with the first few injections, as the initial dose should be kept low to avoid a prolonged erection. TriMix injection is a medication that is very customized to the patient’s needs.

Do TriMix injections hurt?

Although the penis is a sensitive area, you may be surprised to find that the discomfort that comes with injections is very minimal. TriMix injections are actually given in the shaft of the penis (not the head), which has very few nerve endings. Most men who use TriMix adjust quickly to administering the injections after the first use.

Are there side effects to using TriMix?

Oral medication is systemic (meaning they circulate through the bloodstream), which can cause headaches, nausea, vomiting, etc. But because TriMix injections are localized (injected to only one part of the body), there are generally no side effects associated with this type of medication.

Although infrequent, a more serious side effect of the injection may include priapism (an erection lasting more than four hours) and must be treated immediately to prevent further complications if diagnosed. The same risk, however, is involved with using other ED medication alternatives like Viagra®, Levitra® and Cialis®. Learn more about the side effects of TriMix injections now.

Do I need a prescription to buy TriMix injections?

Yes, the erectile dysfunction medications do require a prescription from a licensed physician

How should I store my TriMix injections?

If your prescription is for more than one vial of medication, store your medication as follows:

– Store only one vial (the vial that’s actively being used) at normal refrigeration temperature (32–39°F).

– The remaining vials (not actively been used) should be placed in the freezer and kept frozen (0–31°F).

– When the active vial (the refrigerated vial) starts running low, remove a vial from the freezer and place it in the refrigerator. When the first vial runs out of medication, replace it with the new active vial.

– Repeat the process and refill medication when only one vial remains in the freezer. 

My TriMix medication just arrived with unfrozen ice packs. Is my medication compromised?

No. TriMix is shipped with ice packs, but it’s normal for the packs to melt and arrive to you unfrozen, or even slightly warm. The medication’s effectiveness is not compromised.

Does alcohol impact the effectiveness of the medication?

Consuming alcohol is not a factor in the effectiveness of the medication (unlike other alternative medications). It is advised, however, to use the injections prior to drinking alcohol for the highest chance of safe administering.

I have diabetes. Are TriMix injections still safe for me to use?

Yes. TriMix was designed to be safe for individuals with diabetes, heart problems or circulation issues. It’s also safe for those who have had prostate surgery, prostate removal or prostate cancer.

Want to Learn More About TriMix?